apalutamide will decrease the level or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medicine that are CYP3A4 substrates can lead to decreased exposure to these medicines.Xanax is not a narcotic. Xanax is a prescription medica… Read More